疾病的影响远不止身高。患儿常伴随中耳炎、脊柱侧弯、关节功能异常等并发症，严重的枕骨大孔狭窄甚至可能压迫脊髓、导致呼吸暂停，存在致命风险。
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For almost a year, Matthew Smith woke up every day wondering if he would receive the phonecall that would save his life.，这一点在heLLoword翻译官方下载中也有详细论述